For the first time in over a decade, there is new guidance on the use of hormone-replacement therapy to treat symptoms of menopause.

ABC News medical correspondent Dr. Darien Sutton reports.

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Lama Hasan has the latest from Pope Leo XIV makes his first public appearance leading the crowd in prayer at the Vatican after undergoing lung cancer surgery. Leslie Lopez tracks the path of a dangerous nor-easter brewing along the Mid-Atlantic and Carolina coasts; Alex Presha on the deadly Canadian military base fire killing at least four people and injuring dozens; Alex Stone reports new images of the police raiding the 16 year-old school shooting suspect; Steve Portnoy reports on the campaign trail as Republicans scramble to hold control of congress with the midterms just 16 days away; and more on tonight’s broadcast of World News Tonight with David Muir.

00:00 Intro
02:06 Pope makes 1st appearance after surgery for lung cancer
04:06 Dangerous nor’easter threatening Mid-Atlantic and Carolina coasts
05:11 Four killed and thirty-nine injured after fire on Canadian military base according to authorities
06:49 New details in Oregon elementary school shooting
08:19 New poll numbers as United States is now sixteen days from mid-term elections
09:57 Linsey Davis speaks one-on-one with Michigan candidates El-Sayed
10:58 Republican U.S. Senate candidate Mike Rogers plans to address inflation and rising prices
11:53 Trump faces backlash after deciding to waive sanctions and tariffs on Russia
12:51 Police: 34-year-old drove into children’s soccer game killing 2, injuring 11
14:03 Plane crashes onto busy California intersection following engine failure after takeoff
15:19 Thousands of arrests amid protesters and chaos across France
16:32 NYT Report: informant allegedly told police about missing murder weapon from O.J. Case
17:50 Urgent investigation into how an airman died in a pregame event
18:11 FlyDubai Pilot speaks out for the first time since alleged attempted hijacking
18:42 Big 12 conference says they will review controversial end to Notre Dame versus BYU game
19:02 Cindy Crawford posts emotional tribute honoring late son
19:26 The Brewers’ national league MVP and the two fans cheering him from the start

ABC World News Tonight with David Muir delivers the news that matters most. Watch to get the latest news stories and headlines from around the world.

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Jalen Hurts, the Philadelphia Eagles star quarterback, is out for the rest of the season after doctors discovered a blood clot in his leg and clots in both his lungs. The former Super Bowl MVP is expected to make a full recovery. Rhiannon Ally has details.

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CNN’s Victoria Arbiter says in many ways Duchess Catherine is following in the footsteps of Princess Diana. More from CNN at http://www.cnn.com/

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Stream 20/20’s “The Suitcase Murders” on Disney+ and Hulu, under Season 49, Episode 4.
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