Leslie Lopez reports on the millions facing the aftermath of Hurricane Isaias, a powerful category 2 at landfall blamed for four deaths with the remnants now sweeping up the east coast spawning tornadoes and flash flood threats; Tom Soufi Burridge has the details on the unexpected announcement from Pope Leo, the first American pontiff revealing he will undergo surgery to remove a nodule on his lung; Steven Portnoy has the latest on President Trump facing backlash from lawmakers on both sides of the aisle for lashing out at Ukraine’s President while announcing that Russia and Ukraine have agreed to an energy ceasefire; and more on tonight’s broadcast of World News Tonight with David Muir.

02:01 Dangerous weather battering the east coast as hundreds of thousands remain without power
04:23 Remnants of Tropical Storm Rachel combine with another system creating dangerous conditions
06:06 Tracking dangerous flooding across U.S.
06:46 Pope Leo revealed he will undergo surgery to remove a nodule on his lung
07:47 Trump facing backlash from lawmakers on both sides of the aisle for lashing out at Ukraine’s Pres.
09:55 President Trump considering joining Saudi Arabia’s fight against the Houthi rebels
11:05 Growing outrage and a demand for answers after unmarked ICE suv struck a man during a pursuit
12:50 Terrifying incident after man was mauled to death when he entered a tiger’s enclosure
14:03 Christa Pike back in prison after being released from hospital
15:00 Growing signs of Republican concern ahead of midterm elections
17:00 Thieves make off with more than thirty thousand bottles of wine
17:19 Three men seen climbing into sewer system in New York City
17:48 Cleveland Guardians clinch the final spot in the Major League playoffs
18:05 Soccer star Cristiano Ronaldo has been suspended from Portuguese National Team
18:23 Northern lights may be visible tonight in parts of the Northern United States
18:50 Bowler turns 100

ABC World News Tonight with David Muir delivers the news that matters most. Watch to get the latest news stories and headlines from around the world.

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Ukrainian President Volodymyr Zelenskyy joins ‘This Week’ for an exclusive interview after President Trump called for him to be replaced. Kansas Senate candidate Adam Hamilton discusses his bid to become the first Democratic senator from the state in almost 100 years. As the midterms approach, House Majority Whip Rep. Tom Emmer talks about his party’s push to maintain control of Congress.

00:00 Intro
03:34 ABC News’ Jon Karl reports on midterm races across the country
07:07 ABC News’ Rachel Scott breaks down high-stakes races
09:17 Kansas Democratic Senate candidate Adam Hamilton discusses his bid for Senate
19:32 Ukrainian President Volodymyr Zelenskyy discusses President Trump’s diesel deal with Russia
28:24 Rep. Tom Emmer discusses his party’s push to the midterms
35:33 The Powerhouse Roundtable breaks down the week’s politics

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The highly anticipated preliminary hearing in the murder case against singer D4vd continued Wednesday in Los Angeles. ABC News’ Alex Stone has the latest.

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BREAKING: NASA SpaceX’s Crew-12 is back on Earth after a successful splashdown in the Pacific off the coast of Los Angeles.

The crew spent 235 days on the International Space Station and orbited Earth nearly 3,800 times, conducting scientific experiments and performing station maintenance.

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A 45-year-old man shot eight people, mostly family members, before taking his own life, police said.

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